Cancer to Bone: A Fatal Attraction
Katherine N. Weilbaecher, Theresa A. Guise & Laurie K. McCauley
When cancer metastasizes to bone, considerable pain and deregulated bone remodeling occurs, greatly diminishing the possibility of cure. Metastasizing tumor cells mobilize and sculpt the bone microenvironment to enhance tumor growth and to promote bone invasion. Understanding the crucial components of the bone microenvironment that influence tumor localization, along with the tumor-derived factors that modulate cellular and protein matrix components of bone to favor tumor expansion and invasion, is central to the pathophysiology of bone metastases. Basic findings of tumor-bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases.